3-hydroxy-6-benzo[c]chromenone
Urolithin B
CAS: 1139-83-9
Molecular Formula: C13H8O3
3-hydroxy-6-benzo[c]chromenone - Names and Identifiers
| Name | Urolithin B |
| Synonyms | AURORA 226 Urolithin B AKOS BBS-00008028 3-hydroxybenzo[c]chromen-6-one 3-hydroxy-6-benzo[c]chromenone 3-Hydroxy-benzo[c]chromen-6-one 3-HYDROXY-6H-DIBENZO[B,D]PYRAN-6-ONE 3-Hydroxy-6H-benzo[c]chromen-6-one AldrichCPR |
| CAS | 1139-83-9 |
| InChI | InChIKey=WXUQMTRHPNOXBV-UHFFFAOYSA-N |
| InChIKey | WXUQMTRHPNOXBV-UHFFFAOYSA-N |
3-hydroxy-6-benzo[c]chromenone - Physico-chemical Properties
| Molecular Formula | C13H8O3 |
| Molar Mass | 212.2 |
| Density | 1.395±0.06 g/cm3(Predicted) |
| Melting Point | 247 °C |
| Boling Point | 432.6±24.0 °C(Predicted) |
| Water Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Appearance | White powder |
| Color | white to beige |
| pKa | 9.03±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| MDL | MFCD00034338 |
| Physical and Chemical Properties | Storage conditions 2-8°C Acidity coefficient (pKa) 9.03±0.20(Predicted) Morphology powder Color white to beige |
3-hydroxy-6-benzo[c]chromenone - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
3-hydroxy-6-benzo[c]chromenone - Reference
| Reference Show more | 1. Li, P, Du, R, Chen, Z, et al. Punicalagin is a neuraminidase inhibitor of influenza viruses. J Med Virol. 2021; 93: 3465– 3472. https://doi.org/10.1002/jmv.26449 2. [IF=4.952] Yuxin Hao et al."Stability and mechanism of phenolic compounds from raspberry extract under in vitro gastrointestinal digestion."Lwt Food Sci Technol. 2021 Mar;139:110552 3. [IF=2.327] Ping Li et al."Punicalagin is a neuraminidase inhibitor of influenza viruses."J Med Virol. 2021 Jun;93(6):3465-3472 4. [IF=4.24] Peiyu Xue et al."Serum albumin complexed with ellagic acid from pomegranate peel and its metabolite urolithin B."Food Biosci. 2022 Apr;46:101618 |
3-hydroxy-6-benzo[c]chromenone - Nature
| melting point | 247 °C |
| boiling point | 432.6±24.0 °C(Predicted) |
| density | 1.395±0.06 g/cm3(Predicted) |
| storage conditions | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| acidity coefficient (pKa) | 9.03±0.20(Predicted) |
| morphology | powder |
| color | white to beige |
| InChIKey | WXUQMTRHPNOXBV-UHFFFAOYSA-N |
Last Update：2024-04-10 22:29:15
3-hydroxy-6-benzo[c]chromenone - Reference Information
| use | 3-hydroxy-6H-benzo [C] benzopyran-6-one is a ketone derivative and can be used as a reference substance. |
| Biological activity | Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα. Urolithin B can inhibit the phosphorylation of JNK, ERK and Akt, and enhance the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass. |
| target | TargetValue iκbα () NF-κB () JNK () ERK () Akt () click more |
| Target | Value |
Last Update：2024-04-09 21:31:57
3-hydroxy-6-benzo[c]chromenone - Uses and synthesis methods
| use | 3-hydroxy-6H-benzo [C] benzopyran-6-one is a ketone derivative and can be used as a reference substance. |
| biological activity | Urolithin B inhibits NF-& kappa;B activity by reducing I & kappa; Phosphorylation and degradation of B α. Urolithin B can inhibit phosphorylation of JNK, ERK and Akt, and enhance phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass. |
Last Update：2024-04-09 21:31:46
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CAS: 1139-83-9
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